利巴韦林联合干扰素治疗丙肝影响男性性功能

收藏分享 2009-9-19 12:53| 发布者: tianniao| 查看数: 95| 评论数: 0

一项研究表明：正在接受抗病毒药物聚乙二醇干扰素和利巴韦林治疗丙肝的男性常常会有性功能障碍。目前这种联合用药是丙肝治疗的标准疗法，研究人员发现其具有影响性健康的全部三要素的可能，包括性欲，性功能和性满足感。Lorna M. Dove 及其同事建议打算接受聚乙二醇干扰素和利巴韦林联合治疗的男性应该被告知在治疗过程中性健康衰退的可能性并且接受足够的支持一旦这些副作用发生。丙肝是一种血液传播疾病，其通常没有症状但是能够在肝脏中导致炎症和肝硬化，并且在极少数的病例中导致肝癌。丙肝通常是通过输入没有筛查的血或者通过注射或者吸入药物被感染。慢性丙肝影响1%到2%的美国人并且在非洲裔美国人中比高加索裔以及其他种族的美国人群中更常见。DOVE和其同事发现患有慢性丙肝的男性的性健康在联合治疗前，治疗中以及治疗后没有很好的被研究。当前研究显示在男性中这种治疗的常见副作用是性功能和性欲望的受损，并且这些副作用在治疗结束后常常不能完全消失。作为一项大型研究的一部分，260名接受联合治疗的男性完成了关于治疗前中后的性健康的调查问卷。在治疗前，37%的男性报告轻度的性驱动力的损害，26%报道勃起机能障碍，22%报道****异常，44%报道对性生活不满意。在治疗24周或者是48周终点时，38%-48%的男性报道他们低下的性功能比治疗前恶化。在治疗过程中整体上非洲裔男性美国人性功能损伤程度较高加索裔美国人损伤程度轻。研究人员发现在24周终止治疗的患者，在治疗结束后6月他们的性健康恢复到接近正常。和治疗前成比例，接受48治疗的男性报道较高的勃起和****问题，尽管在永久的勃起损害仅限于高加索裔美国男性中。

医学岛推荐原文：
NEW YORK (Reuters Health) – Men taking the antiviral drugs peginterferon and ribavirin for chronic hepatitis C virus infection often experience sexual dysfunction, results of a study indicate.

This drug combination, which is standard therapy for chronic hepatitis C, has the potential to impact all three components of sexual health: desire, function and satisfaction, the researchers found.

"Men planning to receive peginterferon and ribavirin should be counseled about the possibility of a decline in sexual health during treatment and receive adequate support if these side effects occur," Dr. Lorna M. Dove of New York Presbyterian Medical Center and colleagues suggest in the journal Gastroenterology.

Hepatitis C is a blood-borne infectious disease that is often without symptoms and can cause inflammation of the liver, cirrhosis, and in extreme cases, liver cancer. It is usually contracted through transfusions of unscreened blood, or by injecting or inhaling drugs.

Chronic hepatitis C affects 1 percent to 2 percent of the American population and is more common among African Americans than Caucasian Americans and other racial and ethnic groups in the U.S.

The sexual health of men with chronic hepatitis C before, during, and after combination therapy has not been well studied, Dove and colleagues note.

The current study shows that impairments in sexual function and desire are common side effects of this therapy in men, and these effects are not always completely reversed after therapy is stopped.

As part of a large study, 260 men treated with peginterferon and ribavirin completed questionnaires about sexual health before, during and after therapy.

Prior to treatment, 37 percent reported mild impairment in their sex drive, 26 percent reported erectile dysfunction, 22 percent reported ejaculation trouble, and 44 percent reported dissatisfaction with their sex life.

By the end of therapy at either 24 or 48 weeks, 38 percent to 48 percent of men reported that their lower sexual function was worse than before treatment. African American men reported less impairment overall than Caucasian American men during treatment.

For patients who stopped therapy at 24 weeks, sexual health returned to near normal within 6 months of the end of treatment, the researchers found.

Relative to before treatment, men receiving treatment for 48 weeks reported higher erectile and ejaculation problems, although persistent erectile impairment was limited to Caucasian American men.

SOURCE: Gastroenterology, September 2009.

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