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| ScienceDaily（2009年11月2日） -世界各地有数百万人使用他汀类药物降低血胆固醇，根据哥德堡大学的一项新的研究，在癌症，糖尿病治疗等方面，他汀类药物也可能发挥更多作用。 他 汀类药物通过抑制与机体代谢有关的某些酶起到降低胆固醇作用，此外也会影响到其他身体里重要的脂质，如帮助蛋白质附着在细胞膜的脂类（被称为脂质修饰）。 由于许多脂质修饰的蛋白会引起癌症，因此他汀类药物有希望用于癌症的治疗。然而，研究他汀类药物对哺乳动物的副作用是非常困难的。哥德堡大学的研究者们对 线虫C. elegans进行了研究。这种线虫由一千只左右的细胞构成，不产生胆固醇，是理想的研究对象。 研究显示，他汀类药物可以显著 抑制细胞增长，研究人员还成功的确定了有关的酶，从分子水平上阐释了作用机制。研究的结果肯定了之前的观点，他汀类药物可以用在更多的方面，而不仅仅是降 低胆固醇----它们不仅可以抑制由脂质修饰蛋白引起的癌细胞的生长，而且可以在糖尿病和神经系统疾病（如帕金森氏病）的治疗上发挥作用。 医学岛推荐原文： ScienceDaily (Nov. 2, 2009) — Millions of people around the world use medicines based on statins to lower their blood cholesterol, but new research from the University of Gothenburg, shows that statins may also be effective in the treatment of cancer. Statins lower cholesterol by blocking certain enzymes involved in our metabolism. However, they have also been shown to affect other important lipids in the body, such as the lipids that help proteins to attach to the cell membrane (known as lipid modification). Because many of the proteins that are lipid-modified cause cancer, there are now hopes that it will be possible to use statins in the treatment of cancer. Ideal test subject It is, however, very difficult to study the side-effects of statins in mammals. As a first step, Marc Pilon, researcher at the Department of Cell and Molecular Biology at the University of Gothenburg, has teamed up with Swedish and international colleagues to carry out studies on the nematode C. elegans. This nematode, which is made up of just a thousand or so cells, does not produce cholesterol and is therefore an ideal test subject. Can treat diabetes The Gothenburg researchers' studies show that statins can have a dramatic inhibitory effect on growth and development. As the researchers managed to identify the enzyme involved, they can also explain how the effect arises at molecular level. "Our results support the idea that statins can be used in more ways than just to lower cholesterol," says Pilon. "Not least that they can prevent the growth of cancer cells caused by lipid-modified proteins, but also that they can be effective in the treatment of diabetes and neurological disorders such as Parkinson's." Journal reference: Catarina Mörck, Louise Olsen, Caroline Kurth, Annelie Persson, Nadia Jin Storm, Emma Svensson, John-Olov Jansson, Annika Enejder, Nils J. Faergeman, and Marc Pilon. Statins Inhibit Protein Lipidation and Induce the Unfolded Protein Response in the Non-Sterol Producing Nematode C. elegans. PNAS, October 27, 2009 vol. 106 no. 43 18285-18290 DOI: 10.1073/pnas.0907117106 |
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